Client
Services
The Client Services Department is staffed by trained qualified personnel whose primary concern is responding to telephone inquiries and contacting customers to provide
information. Client Services Representatives answer questions or concerns regarding specimen requirements, turnaround time, patient results, test add requests and
miscellaneous other inquiries through effective use of the laboratory information systems. They also appropriately channel calls to specific individuals for technical or
interpretive information and dispatch couriers to meet clients' needs. Together with the Central Processing and Accessioning, Distribution and Technical staffs, they assure
excellent quality and rapid result delivery. Client Services Representatives may be contacted at
(216) 444-5755 or (800) 628-6816, or via email at ClientServices@ccf.org.
Distribution
Services
Cleveland Clinic Reference Laboratory provides local courier services to clients in the metropolitan and surrounding areas. Reference Laboratory Distribution Service
Representatives pick up specimens and deliver reports and supplies to clients on a scheduled basis. For further information, call the Client Services Department.
Consultation
Services
Staff pathologists and PhDs are available for consultation upon request. Call the
Client Services Department to arrange such services.
Operational
Hours
Cleveland Clinic Reference Laboratory is in operation twenty-four hours per day, seven days per week. Tests are performed according to a defined production schedule
based on need and methodology.
Holiday Hours
Cleveland Clinic Reference Laboratory recognizes the following as official holidays:
| New Year's Day |
January 1st |
| Memorial Day |
Last Monday in May |
| Independence Day |
July 4th |
| Labor Day |
1st Monday in September |
| Thanksgiving |
4th Thursday in November |
| December Holiday |
The day prior to or following Christmas |
| Christmas |
December 25th |
Production schedules are adjusted to meet the varied workflow of holiday seasons but required STAT testing is provided as needed. Holidays which occur on weekends are
observed on Friday or Monday. Notices are sent to clients in advance of each holiday and special pick-up or testing arrangements are made as needed.
Quality Assurance
Extensive proficiency testing and quality control measures assure that each specimen is provided the full benefits of in-house quality, expertise and knowledge. Staff
pathologists, PhDs, laboratory scientists and technologists are all highly experienced in handling complex tests. The Quality Coordinating Team and senior management monitor performance indicators for all laboratory services. Performance improvement initiatives are regularly instituted and reviewed as part of an aggressive on-going quality
improvement program. Telephone calls in the Client Services department are monitored and recorded for quality assurance.
Accreditation
Centers for Medicare and Medicaid Services (CMS/CLIA) - PDF
ODH/CLIA Update - PDF |
| College of American Pathologists (CAP) -
PDF |
| State of Florida - Clinical
Laboratory Certificate - PDF |
Supplies
All supplies required to collect and transport laboratory specimens to the Reference Laboratory
at the Cleveland Clinic are available by contacting
Client Services or by submitting a
Supply Order Form (PDF;
provided by the Distribution Service representatives). Supplies provided include serum and urine transfer tubes, specimen transport bags and special
collection materials described in the Test
Directory. Order supplies in advance to facilitate timely delivery.
Specimen collection devices supplied by the Cleveland Clinic Reference Laboratory
are to be used only for the collection of specimens to be sent to this laboratory. The
supplies are not to be used to store or dispose of biological materials or sharp instruments or for any activity not connected with the collection of specimens being referred
to this laboratory.
Allergens
(Individual)
Please clearly print the complete name of each required allergen on the Test
Request Form (PDF).
Specimen Requirements: 0.1mL serum per allergen. Separate serum from cells ASAP. Hemolyzed, icteric or lipemic serum is unacceptable. (Min: 0.1mL)
Methodology: Fluorescent Enzyme Immunoassay
Reference Range:
| |
Value (kU/L) |
Level |
| Class 00 |
< 0.35 |
Undetectable |
| Class 01 |
0.35 - 0.69 |
Low |
| Class 02 |
0.70 - 3.49 |
Moderate |
| Class 03 |
3.50 - 17.49 |
Very High |
| Class 04 |
17.50 - 49.99 |
Very High |
| Class 05 |
50.00 - 99.99 |
Very High |
| Class 06 |
>100.00 |
Very High |
| Drugs |
- Penicilloyl G
|
- Penicilloyl V
|
|
|
| Dust and Mites |
- Dermatophagoides farinae
-Dermatophagoides
pteronyssinus
|
- Dust, Hollister Stiers Labs
- Dust, Greer Labs
|
|
|
| Epidermals |
- Cat dander
- Chicken feathers
- Cow dander
- Dog dander
|
- Dog epithelium
- Feathers (goose,
chicken, duck,
turkey)*
|
- Goose feathers
- Horse dander
|
- Pigeon droppings*
- Sheep epithelium
|
| Foods |
- Almond
- Apple
- Avocado*
- Banana*
- Barley
- Beef
- Buckwheat
- Cacao (Cocoa)
- Carrot
- Casein
- Celery
- Cheese,
mold type
|
- Cheese,
cheddar type
- Chicken
- Coconut
- Cod fish
- Corn (Maize)
- Cow's milk
- Crab
- Egg white
- Egg yolk
- Gluten
- Kidney bean*
- Lettuce
|
- Lobster
- Oat
- Onion*
- Orange
- Parsley
- Pea
- Peanut
- Pecan nut
- Pork
- Potato
- Rice
- Rye
|
- Sesame seed
- Shrimp
- Soybean
- Strawberry
- Sweet chestnut
- Tomato
- Tuna
- Wheat
- Whey*
- White bean
- Yeast
|
| Grasses
|
- Bahia grass
- Bermuda grass
- Johnson grass
- June, Meadow,
Kentucky
Blue
grass
|
- Meadow fescue
- Orchard grass
(Cocksfoot)
- Perennial Rye grass
|
- Redtop grass (Bentgrass)
- Sweet vernal grass
|
- Timothy grass
|
| Insects
& Venoms |
- Cockroach
- Honey bee
- Paper wasp
|
- White hornet
- Yellow hornet
- Yellow jacket (Common
wasp)
|
|
|
| Molds |
- Alternaria tenuis (alternata)
- Aspergillus fumigatus
|
- Aspergillus niger*
- Candida albicans
|
- Cladosporium herbarum
- Mucor racemosus*
|
- Penicillium notatum
- Trichophyton rubrum
|
| Occupational |
- Latex
|
|
|
|
| Trees |
- Australia pine
tree*
- Common Silver Birch tree
- Cotton
wood tree
|
- Elm tree
- Hickory, Pecan tree
- Maple, Box Elder
|
- Melaleuca,
Cajeput tree
- Oak tree
- Walnut tree
|
- White Pine tree
- Willow tree
|
| Weeds |
- Dandelion
- English plantain
- Firebush (Kocia)
- Giant ragweed
|
- Golden Rod
- Lamb's quarters, Goosefoot
- Pigweed
|
- Rough marshelder
- Russian thistle, Saltwort
- Sheep
sorrel
|
- Short (common) ragweed
|
* Assay is for investigational use only and is not approved for diagnostic purposes.
Allergens (Panels)
ANIMAL GROUP
Test Code: ANIMALS
Billing Code: 41450
Specimen: 1.0mL serum
|
Chicken Feathers
Cow Dander
Goose Feathers |
Horse Dander
Pigeon Droppings |
|
ANIMAL GROUP
RL
Test Code: ANIMH
Billing Code: 79180
Specimen: 1.0mL serum
|
Cat
Epithelium
Dog Epithelium
Dog Dander |
Goose
Feathers
Sheep Epithelium |
|
CEREAL GROUP
Test Code: CEREAL
Billing Code: 41560
Specimen: 1.0mL serum
|
Barley
Buckwheat
Gluten |
Rice
Rye |
|
FOOD
GROUP
Test Code: FOODS
Billing Code: 41330
Specimen: 1.5mL serum
|
Corn
Crab
Egg White
Milk |
Orange
Peanut
Shrimp
Soybean |
Tuna
Wheat |
FOOD
GROUP RL
Test Code: FOODRL
Billing Code: 179
Specimen: 3.0mL serum |
Banana
Barley
Beef
Cheese, Chedder
Chiken
Corn
Egg White |
Gluten
Milk
Oats
Orange
Peanut
Pork
Potato |
Rice
Rye
Soybean
Tomato
Wheat
Yeast |
GRASS
GROUP
Test Code: GRASS
Billing Code: 41460
Specimen: 1.0mL serum
|
Meadow Fescue
Orchard
Redtop (Bent)
|
Rye Grass
Sweet Vernal |
|
INHALANT
GROUP (GREAT LAKES)
Test Code: INHALR
Billing Code: 41010
Specimen: 1.5mL serum
|
Alternaria tenuis
Cat Dander
Cladosporium herbarum
Common Ragweed |
Dermatophagoides farinae
Dog Dander
June/Kentucky Blue Grass |
Lamb's Quarters
Oak
Timothy Grass |
INHALANTS
GROUP
Test Code: INHALE
Billing Code: 41220
Specimen: 2.0mL serum |
A. Fumigatus
Alternaria tenuis
Box Elder
C. Herbarium
Cat Epithelium |
D. farinae
Dog Dander
English Plantain
House Dust
June Grass
|
Lamb's Quarters
Oak
P. notatum
Short Ragweed
Timothy Grass |
MOLD
GROUP
Test Code: MOLDS
Billing Code: 41170
Specimen: 1.0mL serum
|
Alternaria tenuis
Aspergillus fumigatus
Candida albicans
|
Cladosporium herbarum
Mucor racemosus |
|
NUT
MIX GROUP
Test Code: NUTMIX
Billing Code: 41610
Specimen: 1.0mL serum
|
Almond
Coconut
Peanut
|
Pecan Nut
Sesame Seed |
|
PEDIATRIC
GROUP
Test Code: PEDTRC
Billing Code: 41490
Specimen: 1.0mL serum
|
Egg White
Milk
Oat
|
Soybean
Wheat |
|
PEDIATRIC
GROUP RL
Test Code: PEDMH
Billing Code: 79434
Specimen: 1.5mL serum
|
Barley
Casein
CodfishCorn
Egg White |
Oats
Rye
Shrimp
Soybean |
Tuna
Wheat
Whey |
PENICILIN
GROUP
Test Code: PENCLS
Billing Code: 41520
Specimen: 0.2mL serum
|
Penicilloyl G
Penicilloyl V |
|
|
RAST
SCREEN
Test Code: SCR
Billing Code: 56
Specimen: 4.0mL serum
|
A. fumigatus
A. tenuis
Barley
Box Elder
Cat Epithelium
Corn
D. farinae
Dog Epithelium
Egg White
English Plantain
Giant Ragweed |
Horse Dander
House Dust
Milk
Oak
Oat
Orange
Pea
Peanut
Pork
Potato
Rice |
Rye
Short Ragweed
Shrimp
Soybean
Sweet Vernal
Timothy Grass
Tomato
Wheat
Willow |
RAST
SCREEN, MINI
Test Code: MINI
Billing Code: 41640
Specimen: 1.5mL serum
|
Alternaria tenuis
Bermuda Grass
Cat Dander
CommonRagweed |
D. farinae (mites)
Dog Epithelium
Elm
English Plantain |
June Grass (Kentucky Blue)
Oak |
RAST
SCREEN RL
Test Code: SCRNRL
Billing Code: 180
Specimen: 1.5mL serum
|
A. niger
Alternaria tenuis
Aspergillus fumigatus
Bermuda Grass
Box Elder
C. albicans
Cat Epithelium
Cladosporium herbarum |
Cockroach
Cottonwood
D. farinae
D. pteronyssinus
Dog Epithelium
English Plantain
Giant Ragweed
Golden Rod |
House Dust
June Grass
Lamb's Quarters
Oak
Penicillium notatum
Timothy Grass
White Pine |
SALAD
GROUP
Test Code: SALAD
Billing Code: 41180
Specimen: 3.0mL serum
|
Celery
Lettuce
Orange |
Parsley
Tomato |
|
SEAFOOD
GROUP
Test Code: SEFOOD
Billing Code: 41510
Specimen: 1.0mL serum
|
Codfish
Crab
Lobster |
Shrimp
Tuna |
|
STINGING
INSECT GROUP
Test Code: INSECT
Billing Code: 41190
Specimen: 1.0mL serum
|
Honeybee Venom
Paper Wasp
White-faced Hornet |
Yellow Hornet
Yellow Jacket |
|
TREE
GROUP
Test Code: TREES
Billing Code: 41480
Specimen: 1.0mL serum
|
Box Elder (Maple)
Cottonwood
Elm |
Pecan (Hickory) Tree
Walnut Tree |
|
VEGTABLE
GROUP
Test Code: VEGGIE
Billing Code: 41390
Specimen: 1.0mL serum
|
Carrot
Corn
Pea |
Potato
White Bean |
|
WEED
GROUP
Test Code: WEEDS
Billing Code: 41470
Specimen: 1.0mL serum
|
English Plantain
Kochia (Firebush)
Marsh Elder |
Pigweed
Sheep Sorrell |
|
LIPID
Reference Ranges
CAD
Risk Classifications
| |
Age |
Sex |
Desirable |
Borderline/High |
High |
| Total Cholesterol |
<20 |
M, F |
75-169 |
170-199 |
>=200 |
| >=20 |
M, F |
100-199 |
200-239 |
>=240 |
| LDL Cholesterol |
<20 |
M, F |
50-109 |
110-129 |
>=130 |
| >=20 |
M, F |
60-129 |
130-159 |
>=160 |
| HDL Cholesterol |
All |
M |
>45 |
36-45 |
<=35 |
| All |
F |
>55 |
36-55 |
>=35 |
| VLDL Cholesterol |
<15 |
M, F |
5-24 |
25-59 |
>=60 |
| >=15 |
M, F |
6-40 |
41-79 |
>=80 |
| Triglycerides |
<15 |
M, F |
25-120 |
121-299 |
>=300 |
| >=15 |
M, F |
30-199 |
200-399 |
>=400 |
Risk Ratio Classifications
| |
CAD Risk |
TC/HDL-C Ratio |
LDL-C/HDL-C |
| Male |
1/2 Average |
3.43 |
1.00 |
| Average |
4.97 |
3.55 |
| 2x Average |
9.55 |
6.25 |
| 3x Average |
23.99 |
7.99 |
| Female |
1/2 Average |
3.27 |
1.47 |
| Average |
4.44 |
3.22 |
| 2x Average |
7.05 |
5.03 |
| 3x Average |
11.04 |
6.14 |
|
Routine Urinalysis |
|
Microscopic
Examination
|
| pH |
4.8-7.8 |
|
WBC |
0-5/hpf |
| Specific Gravity |
1.005-1.030 |
|
RBC |
0-3/hpf |
| Protein |
Negative |
|
Casts (hyaline) |
0/hpf |
| Glucose |
Negative |
|
Yeasts |
0/hpf |
| Ketone |
Negative |
|
Trichomonads |
0/hpf |
| Bilirubin |
Negative |
|
Crystals |
0/hpf |
| Hemoglobin |
Negative |
|
|
|
| Nitrates |
Negative |
|
|
|
| Leukocyte Esterase |
Negative |
|
|
|
| Urobilinogen |
Negative |
|
|
|
| Color |
Yellow |
|
|
|
| Clarity |
Clear |
|
|
|
* Normal Values are highly dependent upon age. Appropriate reference
values are reported through the laboratory computer system.
Immunohistochemistry Stains
| STAIN |
ANTIBODY SPECIFICITY |
| ACTH |
Human Adrenocorticotropic Hormone |
| ACTIN, Muscle Specific |
Human Muscle Actin |
| ACTIN, Smooth Muscle |
Alpha-Smooth Muscle Isoform, Myoepithelium, Etc. |
| AE 1 & 3 |
Keratin Cocktail: 40, 48, 50, 50, 6, 58, 65, 5 kD |
| AFP |
Alpha Fetoprotein |
| ALK-1 |
ALK-1 |
| B72.3 |
Tumor Associated Glycoprotein |
| BCL-2 |
Follicular Lymphoma, Apoptosis Inhibin Protein |
| BCL-6 |
Follicular and Diffuse Lymphomas, Burkitt’s Lymphoma & Lymphocyte Predominant Hodgkin’s Disease |
| BCL-X |
Apoptotic Cell Death in Prostate and Gastric Tumors and Lymphoma |
| BER-EP4 |
Epithelial Antigen |
| BETA HCG |
HCG in Trophoblastic Elements of Germ Cell Tumors |
| BLA 36 |
B Lymphocyte Antigen |
| CALCITONIN |
Calcitonin |
| CALRETININ |
Calcium-binding Protein, Mesothelial Cells |
| CAM 5.2 |
Keratin: 39, 43, 500 kD |
| CD1a |
Cortical Thymocytes-Langerhans Cells |
| CD3 |
T-Cells |
| CD4 |
Helper T |
| CD5 |
Pan T-Cells, B-Cell Subset, Thymic Carcinomas |
| CD7 |
Thymocytes, Immature T Cells, NK Cells |
| CD8 |
T-Cells, Suppressor T |
| CD9 |
Breast Tumors, Melanoma |
| CD10 |
Common Acute Lymphoblastic Leukemia |
| CD15 |
Epithelial / Hodgkin’s / Myeloid |
| CD20 |
Human B-Lymphocyte Antigen |
| CD21 |
Dendritic Cells, B-Cells |
| CD23 |
Activated B-Cells |
| CD30 |
Ki-1: Activated T, B, RS Cells |
| CD31 |
Endothelium (Tumor Angiogenesis) |
| CD34 |
Endothelium–Stem Cells, Stromal Tumors |
| CD35 |
Dendritic Cells |
| CD43 |
T-Cells, B-Cell Subset, Myeloid, Histiocytes, Plasma Cells (Leukosialin) |
| CD44 |
Phagocytic Glycogen-1 |
| CD44V6 |
Breast Malignancies |
| CD45RB |
Leukocyte Common Antigen |
| CD45RO |
Helper, Inducer T-Cells |
| CD56 |
Natural Killer Cells |
| CD57 |
Neural and Neuroendocrine Marker NK Cells, Stromal Tumors |
| CD68 |
Macrophages |
| CD79a |
B-Cells |
| CD95 |
FAS Membrane Protein |
| CD95L |
FAL Ligand (FASL) Membrane Protein |
| CD99 |
Ewings Sarcoma / PNET |
| CEA |
Carcinoembryonic Antigen |
| CHROMOGRANIN |
Chromogranin A |
| CHYMOTRYPSIN |
Histiocytes & Histiocytic Neoplasias |
| CK 5/6 |
Intermediate Filament Protein, Cytokeratin 5/6 |
| CK 7 |
Keratin: 54 kD |
| CK13 |
Intermediate Filament Protein, Cytokeratin 13 |
| CK19 |
Human Cytokeratin 19 Polypeptide |
| CK 20 |
Keratin: 54 kD |
| CMV |
Cytomegalovirus |
| CYCLIN D1 |
Cyclin D1/PRAD-1 Oncogene Product, Mantle Cell |
| CYCLIN E |
Cycline Overexpression-Shortened G1 |
| DESMIN |
Desmin |
| DNA and H&E |
DNA |
| EMA |
Epithelial Membrane Antigen |
| ENOLASE |
Neuron Specific Enolase |
| Erica/Prica |
Estrogen Receptor /Progesterone Receptor |
| FACTOR VIII |
Von Willebrand Factor, Endotheium and Megakaryocytes |
| FACTOR XIIIA |
Fibrohistiocytic Tumors, Dendritic Interstitial Cells |
| FASCIN |
Hodgkin’s Disease, High Grade Breast Carcinoma |
| FSH |
Follicle Stimulating Hormone |
| GCDFP |
Gross Cystic Disease Fluid Protein-15 |
| GFP |
Human Glial Fibrillary Acidic Protein |
| GH |
Growth Hormone |
| GLUCAGON |
Glucagon |
| HbcAg |
Hepatitis B Core Antigen |
| HbsAg |
Hepatitis B Surface Antigen |
| Her-2/neu (Erb – b2) |
Erb-2 Oncoprotein |
| Her-2/neu (FISH) |
Her-2 Overexpression |
| HMB 45 |
Melanoma Associated Marker |
| HPV |
Human Papilloma Virus Subtype |
| IgA |
Immunoglobulin A |
| IgD |
Immunoglobulin D |
| IgG |
Immunoglobulin G |
| IgM |
Immunoglobulin M |
| INHIBIN |
Granulosa Cell Tumor, Sex Cord Stromal Tumor |
| KER 903 |
High Molecular Weight Cytokeratins |
| Kappa |
Kappa Light Chain |
| Lambda |
Lambda Light Chain |
| LH |
Luteinizing Hormone |
| MAST CELL TRYPT |
Human Mast Cells |
| MIB I |
Cell Proliferation Marker |
| MURAMIDASE |
Muramidase/Lysozyme |
| MYELO PO |
Neutrophilic Granulocytes and Monocytes |
| MYOD1 |
Rhabdomyosarcoma |
| MYOGENIN |
Rhabdomyosarcoma |
| MYOGLOBIN |
Human Heart |
| MYOSIN |
Smooth Muscle Myosin |
| NEUROFILAMENT |
Neurofilament |
| NEUTROPHIL ELAS |
Neutrophilic Granulocytes & Their Precusors |
| P53 |
Overexpression of the p53 Oncogene |
| PAP |
Normal Hyperplastic and Neoplastic, Prostatic Cells |
| PCNA |
Proliferating Cell Nuclear Antigen |
| PL |
Prolactin in Pituitary |
| PLAP |
Placental Alkaline Phosphatase, Germ Cell and Adenocarcinoma |
| PSA |
Prostate Specific Antigen |
| S-100 |
S100 Protein |
| SYNAPTOPHYSIN |
Synaptophysin |
| TDT |
Blasts, Immature Lymphocytes |
| THYROGLOBULIN |
Thyroglobulin |
| TIA |
Cytolytic Effector Cells in Lymphocytic Infiltrates |
| TSH |
Thyrotropic Cells of Pituitary |
| VIMENTIN |
Vimentin |
|
Client
Services
Distribution
Services
Consultation
Services
Operational
Hours
Holiday
Hours
Quality
Assurance
Accreditation
Supplies
Allergens
(Individual)
Allergens
(Panels)
LIPID
Reference Ranges
Immunohistochemistry
Stains
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
Top
|